3 papers
stat.AP2025
Subgroup Identification and Individualized Treatment Policies: A Tutorial on the Hybrid Two-Stage Workflow
Nan Miles Xi, Xin Huang, Lin Wang
Patients in clinical studies often exhibit heterogeneous treatment effect (HTE). Classical subgroup analyses provide inferential tools to test for effect modification, while modern…
q-bio.QM2025
Bridging the genotype-phenotype gap with generative artificial intelligence
Yangfan Liu, Xiong Xiong, Yong Liao +18
The genotype-phenotype gap is a persistent barrier to complex trait genetic dissection, worsened by the explosive growth of genomic data (1.5 billion variants identified in the UK…
stat.ME2025
Synergy-Informed Design of Platform Trials for Combination Therapies
Nan Miles Xi, Man Mandy Jin, Lin Wang +1
Combination drug therapies hold significant promise for enhancing treatment efficacy, particularly in fields such as oncology, immunotherapy, and infectious diseases. However, desi…