3 papers
stat.ME2026
From aggressive to conservative early stopping in Bayesian group sequential designs
Zhangyi He, Feng Yu, Suzie Cro +1
Group sequential designs (GSDs) are widely used in confirmatory trials to allow interim monitoring while preserving control of the type I error rate. In the frequentist framework,…
stat.ME2025
A Bayesian model-free dose-finding approach in Phase II clinical trials with the flexibility of historical borrowing
Linxi Han, Qiqi Deng, Feng Yu +1
Accurate dose selection in Phase II trials is critical to the success of subsequent Phase III trials, but suboptimal choices remain a leading cause of trial failure and regulatory…
stat.ME2025
Optimal scheduling of interim analyses in group sequential trials
Zhangyi He, Suzie Cro, Laurent Billot
Group sequential designs (GSDs) are well established and the most commonly used adaptive design in confirmatory clinical trials with interim analyses. However, they remain underuti…