4 papers
DC-Flow: Target-Conditioned Cyclic Peptide Design via Delayed-Coupling Flow Matching
Yitian Wang, Minjie Cheng, Yaning Cui +3
Target-conditioned cyclic peptide design requires coordinating interfacial side chains with macrocyclic closure. Existing end-to-end generators concurrently update geometric and ch…
Systematizing Blockchain Research Themes and Design Patterns: Insights from the University Blockchain Research Initiative (UBRI)
Chien-Chih Chen, Yitian Wang, Emma Nasseri +2
The rapid expansion of blockchain and digital asset ecosystems has intensified the challenge of translating academic research into deployable systems and regulatory frameworks. Whi…
MuCO: Generative Peptide Cyclization Empowered by Multi-stage Conformation Optimization
Yitian Wang, Fanmeng Wang, Angxiao Yue +3
Modeling peptide cyclization is critical for the virtual screening of candidate peptides with desirable physical and pharmaceutical properties. This task is challenging because a c…
Enshrined Proposer Builder Separation in the presence of Maximal Extractable Value
Yitian Wang, Yebo Feng, Yingjiu Li +1
In blockchain systems operating under the Proof-of-Stake (PoS) consensus mechanism, fairness in transaction processing is essential to preserving decentralization and maintaining u…