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cs.LG2026
Hierarchical Contrastive Learning for Multi-Domain Protein-Ligand Binding
Shuo Zhang, Rongqi Hong, Huifeng Zhang +1
Predicting protein-ligand binding affinity remains intractable for multi-domain proteins, where inter-domain dynamics govern molecular recognition. Existing geometric deep learning…
cs.LG2024
SeqProFT: Sequence-only Protein Property Prediction with LoRA Finetuning
Shuo Zhang, Jian K. Liu
Protein language models (PLMs) have demonstrated remarkable capabilities in learning relationships between protein sequences and functions. However, finetuning these large models r…