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cs.LG2026
TwinPurify: Purifying gene expression data to reveal tumor-intrinsic transcriptional programs via self-supervised learning
Zhiwei Zheng, Kevin Bryson
Advances in single-cell and spatial transcriptomic technologies have transformed tumor ecosystem profiling at cellular resolution. However, large scale studies on patient cohorts c…
cs.LG2026
LaCoGSEA: Unsupervised deep learning for pathway analysis via latent correlation
Zhiwei Zheng, Kevin Bryson
Motivation: Pathway enrichment analysis is widely used to interpret gene expression data. Standard approaches, such as GSEA, rely on predefined phenotypic labels and pairwise compa…