5 papers
FTU-Seek: Foundation Model-Guided Hard-Negative Learning for Sparse Functional Tissue Unit Segmentation
Zonghao Liu, Lei Su, Jiguang Yu +4
Functional tissue units (FTUs), including tertiary lymphoid structures (TLSs), blood vessels, and glands, encode localized immune, vascular, and epithelial organization in histopat…
Computational Oncology of Chemotaxis-Driven Tumour--Immune Spatial Patterning and Stability
Zonghao Liu, Jiguang Yu, Lei Su +3
We develop a reaction--diffusion--chemotaxis model for spatial tumour--immune--chemokine dynamics that couples logistic tumour growth, immune-mediated killing, chemokine-dependent…
Mode-Wise Spectral Criteria for Coupled Mass Transport in Hybrid PDE--ODE Tumor Microenvironments
Jiguang Yu, Louis Shuo Wang, Zonghao Liu +1
We study coupled mass transport in a tumor--microenvironment setting with two motile densities and non-motile state switching . The populations diffuse and undergo c…
Chemotactic Feedback Controls Patterning in Hybrid Tumor--Stroma Model
Jiguang Yu, Louis Shuo Wang, Zonghao Liu +1
Motivated by an ongoing collaboration with clinical oncologists and pathologists, we develop a hybrid partial differential equation--ordinary differential equation (PDE--ODE) frame…
A hybrid PDE-ABM model for angiogenesis and tumour microenvironment with application to resistance in cancer treatment
Louis Shuo Wang, Jiguang Yu, Zonghao Liu
The main obstacle to effective cancer treatment is the development of drug resistance, which can be divided into two categories: spontaneous and acquired drug resistance. Non-small…