3 papers
physics.bio-ph2026
Measurement-limited learning of conformational heterogeneity in cryo-electron microscopy
Henry H. Mattingly, Luke Evans, Pilar Cossio
Cryogenic electron microscopy images sample individual biomolecules from their conformational landscapes, offering a route to infer the distributions underlying molecular mechanism…
q-bio.QM2025
Cryo-em images are intrinsically low dimensional
Luke Evans, Octavian-Vlad Murad, Lars Dingeldein +3
Simulation-based inference provides a powerful framework for cryo-electron microscopy, employing neural networks in methods like CryoSBI to infer biomolecular conformations via lea…
physics.data-an2025
Error Breakdown and Sensitivity Analysis of Dynamical Quantities in Markov State Models
Yehor Tuchkov, Luke Evans, Sonya M. Hanson +1
Markov state models (MSMs) are widely employed to analyze the kinetics of complex systems. But despite their effectiveness in many applications, MSMs are prone to systematic or sta…