3 papers
cs.LG2026
Repurposing Protein Language Models for Latent Flow-Based Fitness Optimization
Amaru Caceres Arroyo, Lea Bogensperger, Ahmed Allam +3
Protein fitness optimization is challenged by a vast combinatorial landscape where high-fitness variants are extremely sparse. Many current methods either underperform or require c…
cs.LG2025
A Variational Perspective on Generative Protein Fitness Optimization
Lea Bogensperger, Dominik Narnhofer, Ahmed Allam +2
The goal of protein fitness optimization is to discover new protein variants with enhanced fitness for a given use. The vast search space and the sparsely populated fitness landsca…
math.OC2024
An Adaptively Inexact Method for Bilevel Learning Using Primal-Dual Style Differentiation
Lea Bogensperger, Matthias J. Ehrhardt, Thomas Pock +2
We consider a bilevel learning framework for learning linear operators. In this framework, the learnable parameters are optimized via a loss function that also depends on the minim…