3 papers
cs.LG2026
CDS: Counterfactual Directionality Score for Structured Interventions in Spatial Graphs
Humaira Anzum, Md Ishtyaq Mahmud, Jagan Mohan Reddy Dwarampudi +1
Quantifying directional influence between node populations is a fundamental problem in graph-based modeling, particularly in spatial biological systems where cell-cell interactions…
cs.LG2026
hSNMF: Hybrid Spatially Regularized NMF for Image-Derived Spatial Transcriptomics
Md Ishtyaq Mahmud, Veena Kochat, Suresh Satpati +4
High-resolution spatial transcriptomics platforms, such as Xenium, generate single-cell images that capture both molecular and spatial context, but their extremely high dimensional…
q-bio.GN2025
Benchmarking Dimensionality Reduction Techniques for Spatial Transcriptomics
Md Ishtyaq Mahmud, Veena Kochat, Suresh Satpati +3
We introduce a unified framework for evaluating dimensionality reduction techniques in spatial transcriptomics beyond standard PCA approaches. We benchmark six methods PCA, NMF, au…