4 papers
Understanding the Behaviors of Environment-aware Information Retrieval
Ruifeng Yuan, Chaohao Yuan, David Dai +4
Recent retrieval-augmented generation (RAG) approaches have demonstrated strong capability in handling complex queries, yet current research overlooks a critical challenge: differe…
Lingshu-Cell: A generative cellular world model for transcriptome modeling toward virtual cells
Han Zhang, Guo-Hua Yuan, Chaohao Yuan +6
Modeling cellular states and predicting their responses to perturbations are central challenges in computational biology and the development of virtual cells. Existing foundation m…
Atomas: Hierarchical Alignment on Molecule-Text for Unified Molecule Understanding and Generation
Yikun Zhang, Geyan Ye, Chaohao Yuan +5
Molecule-and-text cross-modal representation learning has emerged as a promising direction for enhancing the quality of molecular representation, thereby improving performance in v…
Annotation-guided Protein Design with Multi-Level Domain Alignment
Chaohao Yuan, Songyou Li, Geyan Ye +6
The core challenge of de novo protein design lies in creating proteins with specific functions or properties, guided by certain conditions. Current models explore to generate prote…