2 papers
stat.ME2026
TWICEBEE: A Two-stage Intra-patient Curve-free Bayesian Decision-Theoretic Dose Escalation Design
Dehua Bi, Katherine Ryan, Sabine Heitzeneder +6
We propose a novel Phase I intra-patient dose-escalation design tailored for multi-cycle immunotherapy settings, in which toxicity at a fixed dose level is clinically expected to d…
stat.ME2025
Balancing the effective sample size in prior across different doses in the curve-free Bayesian decision-theoretic design for dose-finding trials
Jiapeng Xu, Dehua Bi, Shenghua Kelly Fan +2
The primary goal of dose allocation in phase I trials is to minimize patient exposure to subtherapeutic or excessively toxic doses, while accurately recommending a phase II dose th…