4 papers · 1 filter
Beyond Random Splits: Evaluating Drug-Target Affinity Models Under Chemically and Biologically Motivated Distribution Shifts Copy
Minjae Chung, Clara Li, Malar Paavai Muthukumaran +8
Drug-target affinity (DTA) prediction is widely used to prioritize candidate compounds before costly experimental screening. DTA models are often compared under a single data split…
Tree-of-Evidence: Efficient "System 2" Search for Faithful Multimodal Grounding
Micky C. Nnamdi, Benoit L. Marteau, Yishan Zhong +2
Large Multimodal Models (LMMs) achieve state-of-the-art performance in high-stakes domains like healthcare, yet their reasoning remains opaque. Current interpretability methods, su…
KindSleep: Knowledge-Informed Diagnosis of Obstructive Sleep Apnea from Oximetry
Micky C Nnamdi, Wenqi Shi, Cheng Wan +4
Obstructive sleep apnea (OSA) is a sleep disorder that affects nearly one billion people globally and significantly elevates cardiovascular risk. Traditional diagnosis through poly…
Developing Fairness-Aware Task Decomposition to Improve Equity in Post-Spinal Fusion Complication Prediction
Yining Yuan, J. Ben Tamo, Wenqi Shi +5
Fairness in clinical prediction models remains a persistent challenge, particularly in high-stakes applications such as spinal fusion surgery for scoliosis, where patient outcomes…