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20232025
most citedCovariance Matrix Estimation for High-Throughput Biomedical Data with Interconnected Communities

6 citations · 11 across the 6 of their papers we have counts for

collaborators

7 papers

stat.ME2025

Estimate Time-Varying Exposure Effects via Ensemble Learning-based Marginal Structural Model with Application to Adolescent Cognitive Development Study

Zhiwei Zhao, Chixiang Chen, Shuo Chen

Evaluating the effects of time-varying exposures is essential for longitudinal studies. The effect estimation becomes increasingly challenging when dealing with hundreds of time-de…

stat.ME2025

A New Integrative Learning Framework for Integrating Multiple Secondary Outcomes into Primary Outcome Analysis: A Case Study on Liver Health

Daxuan Deng, Peisong Han, Shuo Chen +2

In the era of big data, secondary outcomes have become increasingly important alongside primary outcomes. These secondary outcomes, which can be derived from traditional endpoints…

stat.ME2024

Modeling Interconnected Modules in Multivariate Outcomes: Evaluating the Impact of Alcohol Intake on Plasma Metabolomics

Yifan Yang, Chixiang Chen, Hwiyoung Lee +2

Alcohol consumption has been shown to influence cardiovascular mechanisms in humans, leading to observable alterations in the plasma metabolomic profile. Regression models are comm…

stat.ME2023

Hypothesis testing under uniform-block covariance structures

Yifan Yang, Shuo Chen, Ming Wang

A block covariance structure is widely observed across large-scale and high-dimensional datasets in diverse fields such as biology, medicine, engineering, economics, and finance. T…

stat.ME2023★ 1 cited

An Efficient Data Integration Scheme for Synthesizing Information from Multiple Secondary Datasets for the Parameter Inference of the Main Analysis

Chixiang Chen, Ming Wang, Shuo Chen

Many observational studies and clinical trials collect various secondary outcomes that may be highly correlated with the primary endpoint. These secondary outcomes are often analyz…

stat.ME2023★ 4 cited

Bayesian Nonlinear Tensor Regression with Functional Fused Elastic Net Prior

Shuoli Chen, Kejun He, Shiyuan He +2

Tensor regression methods have been widely used to predict a scalar response from covariates in the form of a multiway array. In many applications, the regions of tensor covariates…

stat.ME2023★ 6 cited

Covariance Matrix Estimation for High-Throughput Biomedical Data with Interconnected Communities

Yifan Yang, Chixiang Chen, Shuo Chen

Estimating a covariance matrix is central to high-dimensional data analysis. Empirical analyses of high-dimensional biomedical data, including genomics, proteomics, microbiome, and…