5 papers
Anchoring Convenience Survey Samples to a Baseline Census for Vaccine Coverage Monitoring in Global Health
Nathaniel Dyrkton, Shomoita Alam, Susan Shepherd +3
While conducting probabilistic surveys is the gold standard for assessing vaccine coverage, implementing these surveys poses challenges for global health. There is a need for more…
Comparison of Simulation-Guided Design to Closed-Form Power Calculations in Planning a Cluster Randomized Trial with Covariate-Constrained Randomization: A Case Study in Rural Chad
Jay JH Park, Rebecca K. Metcalfe, Nathaniel Dyrkton +5
Current practices for designing cluster-randomized trials (cRCTs) typically rely on closed-form formulas for power calculations. For cRCTs using covariate-constrained randomization…
Simulation-Guided Planning of a Target Trial Emulated Cluster Randomized Trial for Mass Small-Quantity Lipid Nutrient Supplementation Combined with Expanded Program on Immunization in Rural Niger
Shomoita Alam, Nathaniel Dyrkton, Susan Shepherd +3
Background: Target trial emulation (TTE) that applies trial design principles to improve the analysis of non-randomized studies is increasingly being used. Applications of TTE to e…
Multivariate regression with missing response data for modelling regional DNA methylation QTLs
Shomoita Alam, Yixiao Zeng, Sasha Bernatsky +5
Identifying genetic regulators of DNA methylation (mQTLs) with multivariate models enhances statistical power, but is challenged by missing data from bisulfite sequencing. Standard…
Estimands and Their Implications for Evidence Synthesis for Oncology: A Simulation Study of Treatment Switching in Meta-Analysis
Rebecca K. Metcalfe, Antonio Remiro-Azócar, Quang Vuong +4
The ICH E9(R1) addendum provides guidelines on accounting for intercurrent events in clinical trials using the estimands framework. However, there has been limited attention to the…