3 papers
stat.AP2025
Comparison of Simulation-Guided Design to Closed-Form Power Calculations in Planning a Cluster Randomized Trial with Covariate-Constrained Randomization: A Case Study in Rural Chad
Jay JH Park, Rebecca K. Metcalfe, Nathaniel Dyrkton +5
Current practices for designing cluster-randomized trials (cRCTs) typically rely on closed-form formulas for power calculations. For cRCTs using covariate-constrained randomization…
stat.ME2024
Target Aggregate Data Adjustment Method for Transportability Analysis Utilizing Summary-Level Data from the Target Population
Yichen Yan, Quang Vuong, Rebecca K Metcalfe +3
Transportability analysis is a causal inference framework used to evaluate the external validity of randomized clinical trials (RCTs) or observational studies. Most existing transp…
stat.ME2024
Estimands and Their Implications for Evidence Synthesis for Oncology: A Simulation Study of Treatment Switching in Meta-Analysis
Rebecca K. Metcalfe, Antonio Remiro-Azócar, Quang Vuong +4
The ICH E9(R1) addendum provides guidelines on accounting for intercurrent events in clinical trials using the estimands framework. However, there has been limited attention to the…