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Physics-driven innovations toward the democratization of proton therapy
Vivek Maradia, Martin Bues
Proton therapy exploits the finite range of charged particles in tissue to achieve dose distributions no photon based modality can replicate. Yet the modality reaches fewer than 1…
AI in Proton Therapy Treatment Planning: A Review
Yuzhen Ding, Hongying Feng, Martin Bues +12
Purpose: Proton therapy provides superior dose conformity compared to photon therapy, but its treatment planning is challenged by sensitivity to anatomical changes, setup/range unc…
Diffusion Transformer-based Universal Dose Denoising for Pencil Beam Scanning Proton Therapy
Yuzhen Ding, Jason Holmes, Hongying Feng +13
Purpose: Intensity-modulated proton therapy (IMPT) offers precise tumor coverage while sparing organs at risk (OARs) in head and neck (H&N) cancer. However, its sensitivity to anat…
Modelling small block aperture in an in-house developed GPU-accelerated Monte Carlo-based dose engine for pencil beam scanning proton therapy
Hongying Feng, Jason M. Holmes, Sujay A. Vora +8
Purpose: To enhance an in-house graphic-processing-unit (GPU) accelerated virtual particle (VP)-based Monte Carlo (MC) proton dose engine (VPMC) to model aperture blocks in both do…
Beam mask and sliding window-facilitated deep learning-based accurate and efficient dose prediction for pencil beam scanning proton therapy
Lian Zhang, Jason M. Holmes, Zhengliang Liu +12
Purpose: To develop a DL-based PBSPT dose prediction workflow with high accuracy and balanced complexity to support on-line adaptive proton therapy clinical decision and subsequent…