4 papers
P2P: Cross-View Population Denoising for Unpaired Single-Cell Perturbation Response Prediction
Haojie Yang, Ran Su
AIVC (AI Virtual Cell) is a learned simulator of cellular behavior across conditions. Predicting how a cell population responds transcriptionally to a genetic perturbation is a cor…
MRFlow: Mechanism-Structured Residual Flow Matching for Virtual Cell Perturbation Prediction
Haojie Yang, Ran Su
Predicting cellular responses to chemical and genetic perturbations is a central test for AI virtual cells, yet many single-cell models reduce each condition to an average expressi…
GRIPNet: Gaussian Radial Intensity Prior Guided Architecture for Pulmonary Nodule Detection in CT
Haojie Yang, Ran Su
Lung cancer causes more deaths than any other malignancy, and low-dose CT screening is the main pathway to early diagnosis. That pathway hinges on the smallest lesions, yet nodules…
CDI-DTI: A Strong Cross-domain Interpretable Drug-Target Interaction Prediction Framework Based on Multi-Strategy Fusion
Xiangyu Li, Haojie Yang, Kaimiao Hu +3
Accurate prediction of drug-target interactions (DTI) is pivotal for drug discovery, yet existing methods often fail to address challenges like cross-domain generalization, cold-st…