4 papers
Subgroup analysis in randomized controlled trials with binary outcomes: dilution and logic-respecting properties
Long-Hao Xu, Yang Han, Tim Friede
Subgroup analysis is routinely used in randomized controlled trials to examine whether treatment effects are homogeneous across patient subgroups or differ because of treatment-eff…
Label Noise Cleaning for Supervised Classification via Bernoulli Random Sampling
Yuxin Liu, Xiong Jin, Yang Han
Label noise - incorrect labels assigned to observations - can substantially degrade the performance of supervised classifiers. This paper proposes a label noise cleaning method bas…
ETZ: A Modeling Principle for Confirmability of Drug-Development Studies
Yujia Sun, Yang Han, Xingya Wang +3
Transitioning from Phase 2 to Phase 3 in drug development, at a rate of 40%, is the most stringent among phase transitions (Hay et al. (2014)). Yet, success rate at Phase…
Counterfactual Uncertainty Quantification of Factual Estimand of Efficacy from Before-and-After Treatment Repeated Measures Randomized Controlled Trials
Xingya Wang, Yang Han, Yushi Liu +2
This article quantifies the uncertainty reduction achievable for \textit{counterfactual} estimand, and cautions against potential bias when the estimand uses Digital Twins. Posed b…