3 papers
q-bio.GN2026
MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis
Manveer Singh Tib
5-aminolevulinic acid (5-ALA) promotes fluorescence-based resection of glioblastoma via protoporphyrin IX (PpIX); however, there is considerable heterogeneity in fluorescence inten…
q-bio.GN2026
CLARA: Clarification of Language Ambiguity through Result Analysis for Natural-Language Cancer Genomics Queries
Pratyush Kumar Shukla, Manveer Singh Tib, Siddhant Garg
A natural language interface can be used to make cancer genomics databases easier to use, but even if a question is perfectly fluent, its scientific meaning can be ambiguous. We pr…
q-bio.GN2026
Evaluating Conformal Reliability of Pathway-Level Transcriptomic Signatures Under Cross-Cohort Shift in Sepsis Mortality Prediction
Pratyush Kumar Shukla, Manveer Singh Tib, Siddhant Garg
Blood transcriptomic profiling enables prognostic modeling by capturing the host immune response at the molecular level. Yet, the within-cohort evaluation strategies employed by ma…