42 citations · 74 across the 11 of their papers we have counts for
11 papers
Unveiling Challenges in Mendelian Randomization for Gene-Environment Interaction
Malka Gorfine, Conghui Qu, Ulrike Peters +1
Many diseases and traits involve a complex interplay between genes and environment, generating significant interest in studying gene-environment interaction through observational d…
Heterogeneity-aware integrative regression for ancestry-specific association studies
Aaron J. Molstad, Yanwei Cai, Alexander P. Reiner +3
Ancestry-specific proteome-wide association studies (PWAS) based on genetically predicted protein expression can reveal complex disease etiology specific to certain ancestral group…
A covariance-enhanced approach to multi-tissue joint eQTL mapping with application to transcriptome-wide association studies
Aaron J. Molstad, Wei Sun, Li Hsu
Transcriptome-wide association studies based on genetically predicted gene expression have the potential to identify novel regions associated with various complex traits. It has be…
Marginalized Frailty-Based Illness-Death Model: Application to the UK-Biobank Survival Data
Malka Gorfine, Nir Keret, Asaf Ben Arie +2
The UK Biobank is a large-scale health resource comprising genetic, environmental and medical information on approximately 500,000 volunteer participants in the UK, recruited at ag…
Gaussian process regression for survival time prediction with genome-wide gene expression
Aaron J. Molstad, Li Hsu, Wei Sun
Predicting the survival time of a cancer patient based on his/her genome-wide gene expression remains a challenging problem. For certain types of cancer, the effects of gene expres…
General Semiparametric Shared Frailty Model Estimation and Simulation with frailtySurv
John V. Monaco, Malka Gorfine, Li Hsu
The R package frailtySurv for simulating and fitting semi-parametric shared frailty models is introduced. Package frailtySurv implements semi-parametric consistent estimators for a…