6 papers
SciHorizon-GENE: Benchmarking LLM for Life Sciences Inference from Gene Knowledge to Functional Understanding
Xiaohan Huang, Meng Xiao, Chuan Qin +4
Large language models (LLMs) have shown growing promise in biomedical research, particularly for knowledge-driven interpretation tasks. However, their ability to reliably reason fr…
From Snapshots to Trajectories: Learning Single-Cell Gene Expression Dynamics via Conditional Flow Matching
Siyu Pu, Qingqing Long, Xiaohan Huang +7
Single-cell RNA sequencing (scRNA-seq) provides high-dimensional profiles of cellular states, enabling data-driven modeling of cellular dynamics over time. In practice, time-resolv…
Comprehend, Divide, and Conquer: Feature Subspace Exploration via Multi-Agent Hierarchical Reinforcement Learning
Weiliang Zhang, Xiaohan Huang, Yi Du +5
Feature selection aims to preprocess the target dataset, find an optimal and most streamlined feature subset, and enhance the downstream machine learning task. Among filter, wrappe…
Knowledge-Guided Biomarker Identification for Label-Free Single-Cell RNA-Seq Data: A Reinforcement Learning Perspective
Meng Xiao, Weiliang Zhang, Xiaohan Huang +4
Gene panel selection aims to identify the most informative genomic biomarkers in label-free genomic datasets. Traditional approaches, which rely on domain expertise, embedded machi…
Collaborative Multi-Agent Reinforcement Learning for Automated Feature Transformation with Graph-Driven Path Optimization
Xiaohan Huang, Dongjie Wang, Zhiyuan Ning +7
Feature transformation methods aim to find an optimal mathematical feature-feature crossing process that generates high-value features and improves the performance of downstream ma…
FastFT: Accelerating Reinforced Feature Transformation via Advanced Exploration Strategies
Tianqi He, Xiaohan Huang, Yi Du +6
Feature Transformation is crucial for classic machine learning that aims to generate feature combinations to enhance the performance of downstream tasks from a data-centric perspec…