47 citations · 106 across the 16 of their papers we have counts for
17 papers
Efficient ensemble stochastic algorithms for agent-based models with spatial predator-prey dynamics
Giacomo Albi, Roberto Chignola, Federica Ferrarese
Experiments in predator-prey systems show the emergence of long-term cycles. Deterministic model typically fails in capturing these behaviors, which emerge from the microscopic int…
Fine-grained simulations of the microenvironment of vascularized tumours
Thierry Fredrich, Heiko Rieger, Roberto Chignola +1
One of many important features of the tumour microenvironment is that it is a place of active Darwinian selection where different tumour clones become adapted to the variety of eco…
Bridging the gap between the micro- and the macro-world of tumors
Roberto Chignola, Edoardo Milotti
At present it is still quite difficult to match the vast knowledge on the behavior of individual tumor cells with macroscopic measurements on clinical tumors. On the modeling side,…
Computational challenges of tumor spheroid modeling
Roberto Chignola, Alessio Del Fabbro, Marcello Farina +1
The speed and the versatility of today's computers open up new opportunities to simulate complex biological systems. Here we review a computational approach recently proposed by us…
Emergent Properties of Tumor Microenvironment in a Real-life Model of Multicell Tumor Spheroids
Edoardo Milotti, Roberto Chignola
Multicellular tumor spheroids are an important {\it in vitro} model of the pre-vascular phase of solid tumors, for sizes well below the diagnostic limit: therefore a biophysical mo…
Ab initio computational modeling of tumor spheroids
Roberto Chignola, Alessio Del Fabbro, Marcello Farina +1
This paper is a review of the VBL project, where we develop and test a numerical simulator of tumor spheroids.