activity
19972019
most citedUniversally Sloppy Parameter Sensitivities in Systems Biology

1.3k citations · 3.9k across the 27 of their papers we have counts for

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Showing cond-mat.stat-mechShow all

5 papers · 1 filter

cond-mat.stat-mech2015★ 9 cited

Sloppiness and Emergent Theories in Physics, Biology, and Beyond

Mark K. Transtrum, Benjamin Machta, Kevin Brown +3

Large scale models of physical phenomena demand the development of new statistical and computational tools in order to be effective. Many such models are `sloppy', i.e., exhibit be…

cond-mat.stat-mech2014★ 46 cited

Two-strain competition in quasi-neutral stochastic disease dynamics

Oleg Kogan, Michael Khasin, Baruch Meerson +2

We develop a new perturbation method for studying quasi-neutral competition in a broad class of stochastic competition models, and apply it to the analysis of fixation of competing…

cond-mat.stat-mech2006★ 172 cited

The sloppy model universality class and the Vandermonde matrix

Joshua J. Waterfall, Fergal P. Casey, Ryan N. Gutenkunst +5

In a variety of contexts, physicists study complex, nonlinear models with many unknown or tunable parameters to explain experimental data. We explain why such systems so often are…

cond-mat.stat-mech2003★ 461 cited

Software systems as complex networks: structure, function, and evolvability of software collaboration graphs

C. R. Myers

Software systems emerge from mere keystrokes to form intricate functional networks connecting many collaborating modules, objects, classes, methods, and subroutines. Building on re…

cond-mat.stat-mech2001★ 1.2k cited

Crackling Noise

James P. Sethna, Karin A. Dahmen, Christopher R. Myers

Crackling noise arises when a system responds to changing external conditions through discrete, impulsive events spanning a broad range of sizes. A wide variety of physical systems…