activity
20042023
most citedSpatial model predicts dispersal and cell turnover cause reduced intra-tumor heterogeneity

537 citations · 1.6k across the 35 of their papers we have counts for

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Showing q-bio.PEShow all

9 papers · 1 filter

q-bio.PE2023

Substrate geometry affects population dynamics in a bacterial biofilm

Witold Postek, Klaudia Staskiewicz, Elin Lilja +1

Biofilms inhabit a range of environments, such as dental plaques or soil micropores, often characterized by intricate, non-even surfaces. However, the impact of surface irregularit…

q-bio.PE2023★ 1 cited

Evolutionary adaptation is facilitated by the presence of lethal genotypes

Viktoria Blavatska, Bartlomiej Waclaw

The adaptation rate in theoretical models of biological evolution increases with the mutation rate but only to a point when mutations into lethal states cause extinction. One would…

q-bio.PE2018★ 6 cited

Reduced adhesion between cells and substrate confers selective advantage in bacterial colonies

Craig Watson, Paul Hush, Joshua Williams +4

Microbial colonies cultured on agar Petri dishes have become a model system to study biological evolution in populations expanding in space. Processes such as clonal segregation an…

q-bio.PE2017

A physics-explicit model of bacterial conjugation shows the stabilizing role of the conjugative junction

Jakub Pastuszak, Bartlomiej Waclaw

Conjugation is a process in which bacteria exchange DNA through a physical connection (conjugative junction) between mating cells. Despite its significance for processes such as th…

q-bio.PE2016★ 23 cited

Antibiotic resistance: a physicist's view

Rosalind Allen, Bartlomiej Waclaw

The problem of antibiotic resistance poses challenges across many disciplines. One such challenge is to understand the fundamental science of how antibiotics work, and how resistan…

q-bio.PE2016

Phenotypic switching can speed up biological evolution of microbes

Andrew C. Tadrowski, Martin R. Evans, Bartlomiej Waclaw

Stochastic phenotype switching has been suggested to play a beneficial role in microbial populations by leading to the division of labour among cells, or ensuring that at least som…