7 papers
Eukaryotes evade information storage-replication rate trade-off with endosymbiont assistance leading to larger genomes
Parthasarathi Sahu, Sashikanta Barik, Koushik Ghosh +1
Genome length varies widely among organisms, from compact genomes of prokaryotes to vast and complex genomes of eukaryotes. In this study, we theoretically identify the evolutionar…
High nucleotide skew palindromic DNA sequences function as replication origins due to their unzipping propensity
Parthasarathi Sahu, Sashikanta Barik, Koushik Ghosh +1
Locations of DNA replication initiation in prokaryotes, called "origins of replication", are well-characterized. However, a mechanistic understanding of the sequence-dependence of…
Joint optimization of replication potential and information storage set the letter size of primordial genetic alphabet
Hemachander Subramanian
The simplest possible informational heteropolymer requires only a two-letter alphabet to be able to store information. The evolutionary choice of four monomers in the informational…
Evolutionary advantage of directional symmetry breaking in self-replicating polymers
Hemachander Subramanian, Robert A. Gatenby
Due to the asymmetric nature of the nucleotides, the extant informational biomolecule, DNA, is constrained to replicate unidirectionally on a template. As a product of molecular ev…
Evolutionary advantage of a broken symmetry in autocatalytic polymers explains fundamental properties of DNA
Hemachander Subramanian, Robert A. Gatenby
The macromolecules that encode and translate information in living systems, DNA and RNA, exhibit distinctive structural asymmetries, including homochirality or mirror image asymmet…
Local lattice distortions around cause in-plane uniaxial magnetic anisotropy in Ga(Mn)As
Hemachander Subramanian, J. E. Han
We theoretically investigate the interplay between local lattice distortions around ion impurity and the ion's magnetic polarization, mediated through spin-orbit cou…
Geometry-induced frustration of magnetization in a planar soft-hard magnetic system
Hemachander Subramanian, J. E. Han
We computationally study the frustrated magnetic configurations of a thin soft magnetic layer with the boundary condition fixed by underlying hard magnets. Driven by geometrical co…