7 papers
Physics-Aligned Deep Learning Enables SERS Resolving and Sequencing of Dynamic Single-Molecule DNA Oligomers in Plasmonic Nanocavity
Kuo Zhan, Peilin Xin, Yingqi Zhao +7
Single-molecule surface-enhanced Raman spectroscopy (SM-SERS) captures dynamic molecular behavior with ultrahigh sensitivity, but its biopolymer analysis is hindered by strong spec…
SERS study of single-live-cell electrical permeabilization dynamics via plasmonic nanotubes
Yuge Liang, Peilin Xin, Enock Adjei Agyekum +6
There is a growing demand for minimally invasive methods to analyze intracellular processes and signaling activities in individual living cells, including the identification of tum…
Label-free SERS Discrimination of Native Proline Hydroxylation at Single-molecule peptide by Deep Learning-assisted plasmonic nanopore
Yingqi Zhao, Kuo Zhan, Pei-Lin Xin +6
Post-translational modifications (PTMs) play essential roles in regulating protein structure, function, and cellular signalling. However, peptide level discrimination of hydroxylat…
Label-free SERS Discrimination of Proline from Hydroxylated Proline at Single-molecule Level Assisted by a Deep Learning Model
Yingqi Zhao, Kuo Zhan, Pei-Lin Xin +4
Discriminating the low-abundance hydroxylated proline from hydroxylated proline is crucial for monitoring diseases and eval-uating therapeutic outcomes that require single-molecule…
Deep learning assisted SERS detection of prolines and hydroxylated prolines using nitrilotriacetic acid functionalized gold nanopillars
Yuan Zhang, Kuo Zhan, Peilin Xin +5
Proline (Pro) is one kind of proteinogenic amino acid and an important signaling molecule in the process of metabolism. Hydroxyproline (Hyp) is a product on Pro oxygen sensing post…
A novel particle-in-well technology for single-molecule sequencing by surface-enhanced Raman spectroscopy
Eva Bozo, Pei-Lin Xin, Yingqi Zhao +5
Single-molecule surface-enhanced Raman spectroscopy based on a particle trapped in a plasmonic nanopores provides a unique method for continued and controlled detection of peptide…
SAPNet: a deep learning model for identification of single-molecule peptide post-translational modifications with surface enhanced Raman spectroscopy
Mulusew W. Yaltaye, Yingqi Zhao, Eva Bozo +4
Nanopore resistive pulse sensors are emerging technologies for single-molecule protein sequencing. But they can hardly detect small post-translational modifications (PTMs) such as…