activity
20242026
most citedLabel-free detection of exosomes from different cellular sources based on surface-enhanced Raman spectroscopy combined with machine learning models

3 citations · 4 across the 8 of their papers we have counts for

collaborators

9 papers

physics.optics2026

Automatic control of gold nanoparticle clustering in plasmonic nanopores based on Raman spectroscopic feedback

Iuliia Sheinman, Yingqi Zhao, Zhendai Huang +5

Plasmonic nanopores have been used to trap single nanoparticles using electric bias for single-molecule surface enhanced Raman spectroscopic (SM-SERS) detection and sequencing. Whi…

physics.optics2026

Physics-Aligned Deep Learning Enables SERS Resolving and Sequencing of Dynamic Single-Molecule DNA Oligomers in Plasmonic Nanocavity

Kuo Zhan, Peilin Xin, Yingqi Zhao +7

Single-molecule surface-enhanced Raman spectroscopy (SM-SERS) captures dynamic molecular behavior with ultrahigh sensitivity, but its biopolymer analysis is hindered by strong spec…

cond-mat.mes-hall2026

AI-Driven SERS for Non-invasive and Label-Free Extracellular Vesicle Detection Across Cellular Origins in Tears and Sweat

Yang Li, Xiaoming Lyu, Ling Xia +5

Wearable sensing technology capable of point-of-care, continuous and non-invasive analysis of exosomes in biofluid such as tears and sweat is an essential part for future personali…

physics.bio-ph2026

Label-free SERS Discrimination of Native Proline Hydroxylation at Single-molecule peptide by Deep Learning-assisted plasmonic nanopore

Yingqi Zhao, Kuo Zhan, Pei-Lin Xin +6

Post-translational modifications (PTMs) play essential roles in regulating protein structure, function, and cellular signalling. However, peptide level discrimination of hydroxylat…

cond-mat.mes-hall2026

Resolving Single-Peptide Phosphorylation Dynamics in Plasmonic Nanopores using Physics-Informed Bi-Path Model

Mulusew W. Yaltaye, Yingqi Zhao, Kuo Zhan +2

Protein phosphorylation provides a dynamic readout of cellular signaling yet remains difficult to detect at low abundance and stoichiometry. Single-molecule surface-enhanced Raman…

physics.optics2025★ 1 cited

Bridging Optical Sensing and Wearable Health Monitoring: A Functionalized Plasmonic Nanopillar for Non-Invasive Sweat Glucose Detection

Ling Liu, Kuo Zhan, Joni Kilpijärvi +8

Continuous glucose monitoring (CGM) is vital for diabetes care, but current systems rely on invasive implants or electrochemical sensors that often cause discomfort and skin irrita…

physics.chem-ph2024

Label-free SERS Discrimination of Proline from Hydroxylated Proline at Single-molecule Level Assisted by a Deep Learning Model

Yingqi Zhao, Kuo Zhan, Pei-Lin Xin +4

Discriminating the low-abundance hydroxylated proline from hydroxylated proline is crucial for monitoring diseases and eval-uating therapeutic outcomes that require single-molecule…

q-bio.BM2024

Deep learning assisted SERS detection of prolines and hydroxylated prolines using nitrilotriacetic acid functionalized gold nanopillars

Yuan Zhang, Kuo Zhan, Peilin Xin +5

Proline (Pro) is one kind of proteinogenic amino acid and an important signaling molecule in the process of metabolism. Hydroxyproline (Hyp) is a product on Pro oxygen sensing post…

q-bio.BM2024★ 3 cited

Label-free detection of exosomes from different cellular sources based on surface-enhanced Raman spectroscopy combined with machine learning models

Yang Li, Xiaoming Lyu, Kuo Zhan +3

Exosomes are significant facilitators of inter-cellular communication that can unveil cell-cell interactions, signaling pathways, regulatory mechanisms and disease diagnostics. Non…