5 papers · 1 filter
TCR-EML: Explainable Model Layers for TCR-pMHC Prediction
Jiarui Li, Zixiang Yin, Zhengming Ding +2
T cell receptor (TCR) recognition of peptide-MHC (pMHC) complexes is a central component of adaptive immunity, with implications for vaccine design, cancer immunotherapy, and autoi…
Quantum Probabilistic Label Refining: Enhancing Label Quality for Robust Image Classification
Fang Qi, Lu Peng, Zhengming Ding
Learning with softmax cross-entropy on one-hot labels often leads to overconfident predictions and poor robustness under noise or perturbations. Label smoothing mitigates this by r…
MIND: Insightful Multi-subject Invariant Neural Decoding
Zixiang Yin, Jiarui Li, Zhengming Ding
Decoding visual signals holds the tantalizing potential to unravel the complexities of cognition and perception. While recent studies have focused on reconstructing visual stimuli…
Rational Multi-Modal Transformers for TCR-pMHC Prediction
Jiarui Li, Zixiang Yin, Zhengming Ding +2
T cell receptor (TCR) recognition of peptide-MHC (pMHC) complexes is fundamental to adaptive immunity and central to the development of T cell-based immunotherapies. While transfor…
Quantifying Cross-Attention Interaction in Transformers for Interpreting TCR-pMHC Binding
Jiarui Li, Zixiang Yin, Haley Smith +3
CD8+ "killer" T cells and CD4+ "helper" T cells play a central role in the adaptive immune system by recognizing antigens presented by Major Histocompatibility Complex (pMHC) molec…