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q-bio.MN2026
A Modular Mechanistic In Silico Model for In Vitro Transcription Process Yield and Product Quality Prediction
Keqi Wang, Keilung Choy, Eli Reiser +10
In vitro transcription (IVT) plays a critical role in the manufacture of mRNA vaccines and therapeutics. Optimizing mRNA yield and ensuring product quality, such as capping efficie…
q-bio.MN2024
Multi-Scale Hybrid Modeling to Predict Cell Culture Process with Metabolic Phase Transitions
Keqi Wang, Sarah W. Harcum, Wei Xie
To advance understanding of cellular metabolism and reduce batch-to-batch variability in cell culture processes, this study introduces a multi-scale hybrid modeling framework desig…
q-bio.MN2024
Adjoint Sensitivity Analysis on Multi-Scale Bioprocess Stochastic Reaction Network
Keilung Choy, Wei Xie
Motivated by the pressing challenges in the digital twin development for biomanufacturing systems, we introduce an adjoint sensitivity analysis (SA) approach to expedite the learni…