3 papers
stat.ME2025
Selection Bias in Hybrid Randomized Controlled Trials using External Controls: A Simulation Study
Han Chang Chiam, Franz König, Martin Posch
Hybrid randomized controlled trials (hybrid RCTs) integrate external control data, such as historical or concurrent data, with data from randomized trials. While numerous frequenti…
stat.ME2025
Covariate adjustment for linear models in estimating treatment effects in randomised clinical trials. Some useful theory to guide simulation
Stephen Senn, Franz König, Martin Posch
Building on key papers that were published in special issues of Biometrics in 1957 and 1982 we propose and develop a three-aspect system for evaluating the effect of fitting covari…
stat.ME2025
Graph Based, Adaptive, Multi Arm, Multiple Endpoint, Two Stage Design
Cyrus Mehta, Ajoy Mukhopadhyay, Martin Posch
The graph based approach to multiple testing is an intuitive method that enables a study team to represent clearly, through a directed graph, its priorities for hierarchical testin…