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stat.ME2025
The permuted score test for robust differential expression analysis
Timothy Barry, Ziang Niu, Eugene Katsevich +1
Negative binomial (NB) regression is a popular method for identifying differentially expressed genes in genomics data, such as bulk and single-cell RNA sequencing data. However, NB…
stat.ME2024
Debiased Estimating Equation Method for Robust and Efficient Mendelian Randomization Using a Large Number of Correlated Weak and Invalid Instruments
Ruoyu Wang, Haoyu Zhang, Xihong Lin
Mendelian randomization (MR) is a widely used tool for causal inference in the presence of unmeasured confounders, which uses single nucleotide polymorphisms (SNPs) as instrumental…
stat.ME2024
HEDE: Heritability estimation in high dimensions by Ensembling Debiased Estimators
Yanke Song, Xihong Lin, Pragya Sur
Estimating heritability remains a significant challenge in statistical genetics. Diverse approaches have emerged over the years that are broadly categorized as either random effect…