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A Soft Penetrable Sphere Colloid Model for the Description of Charge and Excluded Volume Interactions in Antibody Solutions
Peter Schurtenberger, Marco Polimeni, Sophia Marzouk +3
Colloid models have frequently been used to successfully describe the influence of protein-protein interactions on antibody solution properties, but they suffer from inherent probl…
Deciphering Molecular Charge Anisotropy: the Case of Antibody Solutions
Fabrizio Camerin, Susana Marin-Aguilar, Anna Stradner +2
Electrostatic interactions fundamentally govern the structure, stability, and dynamics of charged (bio)matter, yet the impact of heterogeneous and anisotropic charge distributions…
Beyond uniform screening: electrostatic heterogeneity dictates solution structure of complex macromolecules
Fabrizio Camerin, Marco Polimeni, Letizia Tavagnacco +7
The complexity of biomolecular interactions necessitates advanced methodologies to accurately capture their behavior in solution. In this work, we focus on monoclonal antibodies an…
Electrostatics and viscosity are strongly linked in concentrated antibody solutions
Fabrizio Camerin, Marco Polimeni, Anna Stradner +2
Monoclonal antibodies are among the most promising therapeutic agents in modern medicine, yet their formulation into high-concentration solutions for subcutaneous self-administrati…
Combining scattering experiments and colloid theory to characterize charge effects in concentrated antibody solutions
Alessandro Gulotta, Marco Polimeni, Samuel Lenton +5
Charges and their contribution to protein-protein interactions are essential for the key structural and dynamic properties of monoclonal antibody (mAb) solutions. In fact, they inf…