8 papers · 1 filter
Few-step Cofolding with All-Atom Flow Maps
Gianluca Scarpellini, Ron Shprints, Peter Holderrieth +7
All-atom generative modeling of 3D biomolecular complexes has emerged as the dominant paradigm for predicting the structure of proteins and protein-ligand systems. Generating struc…
Diamond Maps: Efficient Reward Alignment via Stochastic Flow Maps
Peter Holderrieth, Douglas Chen, Luca Eyring +7
Flow and diffusion models produce high-quality samples, but adapting them to user preferences or constraints post-training remains costly and brittle, a challenge commonly called r…
GLASS Flows: Transition Sampling for Alignment of Flow and Diffusion Models
Peter Holderrieth, Uriel Singer, Tommi Jaakkola +3
The performance of flow matching and diffusion models can be greatly improved at inference time using reward alignment algorithms, yet efficiency remains a major limitation. While…
LEAPS: A discrete neural sampler via locally equivariant networks
Peter Holderrieth, Michael S. Albergo, Tommi Jaakkola
We propose "LEAPS", an algorithm to sample from discrete distributions known up to normalization by learning a rate matrix of a continuous-time Markov chain (CTMC). LEAPS can be se…
Generator Matching: Generative modeling with arbitrary Markov processes
Peter Holderrieth, Marton Havasi, Jason Yim +6
We introduce Generator Matching, a modality-agnostic framework for generative modeling using arbitrary Markov processes. Generators characterize the infinitesimal evolution of a Ma…
Flow Matching Guide and Code
Yaron Lipman, Marton Havasi, Peter Holderrieth +7
Flow Matching (FM) is a recent framework for generative modeling that has achieved state-of-the-art performance across various domains, including image, video, audio, speech, and b…