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q-bio.TO2007
The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils
E. Candelario-Jalil, D. Alvarez, J. M. Castaneda +4
Several studies suggest that cyclooxygenase-2 contributes to the delayed progression of ischemic brain damage. In this study we examined whether the highly selective cyclooxygenase…
q-bio.TO2007
Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia
E. Candelario-Jalil, D. Alvarez, A. Gonzalez-Falcon +5
Cyclooxygenase-2 is involved in the inflammatory component of the ischemic cascade, playing an important role in the delayed progression of the brain damage. The present study eval…
q-bio.TO2007
Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils
E. Candelario-Jalil, D. Alvarez, N. Merino +1
Metabolism of arachidonic acid by cyclooxygenase is one of the primary sources of reactive oxygen species in the ischemic brain. Neuronal overexpression of cyclooxygenase-2 has rec…