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stat.ME2026
Interpreting Hierarchical Composite Endpoints with Survival and Longitudinal Outcomes: Application to Amyotrophic Lateral Sclerosis Trials
Arlina Shen, Dehua Bi, Ruben P. A. van Eijk +2
Hierarchical composite endpoints combining survival and longitudinal functional outcomes are increasingly used in clinical trials, especially when death precludes subsequent functi…
stat.ME2025
On the two-step hybrid design for augmenting randomized trials using real-world data
Jiapeng Xu, Ruben P. A. van Eijk, Alicia Ellis +8
Hybrid clinical trials, that borrow real-world data (RWD), are gaining interest, especially for rare diseases. They assume RWD and randomized control arm be exchangeable, but viola…