34 citations · 110 across the 9 of their papers we have counts for
10 papers
Two channel compartmentalized microfluidic chip for real time monitoring of the metastatic cascade
Hilaria Mollica, Roberto Palomba, Rosita Primavera +1
Metastases are the primary cause of death in cancer patients. Small animal models are helping in dissecting some of key features in the metastatic cascade. Yet, tools for systemati…
Unraveling the vascular fate of deformable circulating tumor cells via a hierarchical computational model
Pieto Lenarda, Alessandro Coclite, Paolo Decuzzi
Distant spreading of primary lesions is modulated by the vascular dynamics of circulating tumor cells (CTCs) and their ability to establish metastatic niches. While the mechanisms…
Erythrocyte-Inspired Discoidal Polymeric Nanoconstructs carrying Tissue Plasminogen Activator for the Enhanced Lysis of Blood Clots
Marianna Colasuonno, Anna Lisa Palange, Rachida Aid +8
Tissue plasminogen activator (tPA) is the sole approved therapeutic molecule for the treatment of acute ischemic stroke. Yet, only a small percentage of patients could benefit from…
Hierarchical microplates as drug depots with controlled geometry, rigidity and therapeutic efficacy
Martina Di Francesco, Rosita Primavera, Davide Romanelli +7
A variety of microparticles have been proposed for the sustained and localized delivery of drugs whit the objective of increasing therapeutic indexes by circumventing filtering org…
Kinematic and dynamic forcing strategies for predicting the transport of inertial capsules via a combined lattice Boltzmann-Immersed Boundary method
A. Coclite, S. Ranaldo, M. D. De Tullio +2
Modeling the transport of deformable capsules under different flow regimens is crucial in a variety of fields, including oil rheology, blood flow and the dispersion of pollutants.…
Deciphering the relative contribution of vascular inflammation and blood rheology in metastatic spreading
Hilaria Mollica, Alessandro Coclite, Marco E. Miali +5
Vascular adhesion of circulating tumor cells (CTCs) is a key step in cancer spreading. If inflammation is recognized to favor the formation of vascular metastatic niches, little is…