4 papers
Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats
A. Gonzalez-Falcon, E. Candelario-Jalil, M. Garcia-Cabrera +1
Recent experimental evidences indicate that pyruvate, the final metabolite of glycolysis, has a remarkable protective effect against different types of brain injury. The purpose of…
Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia
E. Candelario-Jalil, D. Alvarez, A. Gonzalez-Falcon +5
Cyclooxygenase-2 is involved in the inflammatory component of the ischemic cascade, playing an important role in the delayed progression of the brain damage. The present study eval…
Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat
E. Candelario-Jalil, A. Gonzalez-Falcon, M. Garcia-Cabrera +2
Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved in ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of t…
Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
E Candelario-Jalil, A Gonzalez-Falcon, M Garcia-Cabrera +2
Several studies suggest that cyclooxygenase (COX)-2 plays a pivotal role in the progression of ischaemic brain damage. In the present study, we investigated the effects of selectiv…