4 papers · 1 filter
A conceptual model for the evo-devo role of transposable elements and its implications for the ageing phenomenon
Alessandro Fontana
The Evolvable Soma Theory of Ageing is a recently proposed model that frames development as a continuous process of change accompanying organisms throughout the lifespan. This proc…
Evolution, the mother of age-related diseases
Alessandro Fontana
The evolutionary origins of ageing and age-associated diseases continue to pose a fundamental question in biology. This study is concerned with a recently proposed framework, which…
Evolvable Soma Theory of Ageing: Insights from Computer Simulations
Alessandro Fontana, Marios Kyriazis
Biological evolution continuously refines the design of species, resulting in highly optimised organisms over hundreds of millennia. Intuitively, we expect that random changes-evol…
Why evolution needs the old: a theory of ageing as adaptive force
Alessandro Fontana, Marios Kyriazis
At any moment in time, evolution is faced with a formidable challenge: refining the already highly optimised design of biological species, a feat accomplished through all preceding…