Allosteric communication in Dihydrofolate Reductase: Signaling network and pathways for closed to occluded transition and back

Jie Chen, Ruxandra I. Dima, D. Thirumalai

E. Coli. dihydrofolate reductase (DHFR) undergoes conformational transitions between the closed (CS) and occluded (OS) states which, respectively, describe whether the active site…