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q-bio.QM2025
SarcGraph for High-Throughput Regional Analysis of Sarcomere Organization and Contractile Function in 2D Cardiac Muscle Bundles
Saeed Mohammadzadeh, Yao-Chang Tsan, Aaron Renberg +3
Timelapse images of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide rich information on cell structure and contractile function. However, it is chall…
q-bio.QM2025
Quantifying HiPSC-CM Structural Organization at Scale with Deep Learning-Enhanced SarcGraph
Saeed Mohammadzadeh, Emma Lejeune
In cardiac cells, structural organization is an important indicator of cell maturity and healthy function. Healthy cardiomyocytes exhibit well-aligned morphology with densely packe…