activity
20232026
most citedHotspot-Driven Peptide Design via Multi-Fragment Autoregressive Extension

3 citations · 8 across the 12 of their papers we have counts for

collaborators

13 papers

cs.LG2026

Variable-Length Generative Protein Design via Generalized Poisson Flow

Chaoran Cheng, Zhanghan Ni, Yanru Qu +4

The ability to generate variable-length proteins is crucial in protein design, where the optimal length is often unknown and tightly coupled to designability. Current diffusion- an…

cs.CL2026

LangFlow: Continuous Diffusion Rivals Discrete in Language Modeling

Yuxin Chen, Chumeng Liang, Hangke Sui +4

Continuous diffusion has been the foundation of high-fidelity, controllable, and few-step generation of many data modalities such as images. However, in language modeling, prior co…

cs.CV2026

M3: High-fidelity Text-to-Image Generation via Multi-Modal, Multi-Agent and Multi-Round Visual Reasoning

Bangji Yang, Ruihan Guo, Jiajun Fan +2

Generative models have achieved impressive fidelity in text-to-image synthesis, yet struggle with complex compositional prompts involving multiple constraints. We introduce \textbf…

cs.LG2025

Fine-tuning Flow Matching Generative Models with Intermediate Feedback

Jiajun Fan, Chaoran Cheng, Shuaike Shen +2

Flow-based generative models have shown remarkable success in text-to-image generation, yet fine-tuning them with intermediate feedback remains challenging, especially for continuo…

cs.LG2025

Adaptive Divergence Regularized Policy Optimization for Fine-tuning Generative Models

Jiajun Fan, Tong Wei, Chaoran Cheng +2

Balancing exploration and exploitation during reinforcement learning fine-tuning of generative models presents a critical challenge, as existing approaches rely on fixed divergence…

cs.LG2025★ 1 cited

-Flow: A Unified Framework for Continuous-State Discrete Flow Matching Models

Chaoran Cheng, Jiahan Li, Jiajun Fan +1

Recent efforts have extended the flow-matching framework to discrete generative modeling. One strand of models directly works with the continuous probabilities instead of discrete…

cs.LG2025★ 1 cited

Online Reward-Weighted Fine-Tuning of Flow Matching with Wasserstein Regularization

Jiajun Fan, Shuaike Shen, Chaoran Cheng +3

Recent advancements in reinforcement learning (RL) have achieved great success in fine-tuning diffusion-based generative models. However, fine-tuning continuous flow-based generati…

cs.LG2024

Gradient-Free Generation for Hard-Constrained Systems

Chaoran Cheng, Boran Han, Danielle C. Maddix +4

Generative models that satisfy hard constraints are critical in many scientific and engineering applications, where physical laws or system requirements must be strictly respected.…

cs.CV2024★ 1 cited

Geometric Point Attention Transformer for 3D Shape Reassembly

Jiahan Li, Chaoran Cheng, Jianzhu Ma +1

Shape assembly, which aims to reassemble separate parts into a complete object, has gained significant interest in recent years. Existing methods primarily rely on networks to pred…

q-bio.BM2024★ 3 cited

Hotspot-Driven Peptide Design via Multi-Fragment Autoregressive Extension

Jiahan Li, Tong Chen, Shitong Luo +7

Peptides, short chains of amino acids, interact with target proteins, making them a unique class of protein-based therapeutics for treating human diseases. Recently, deep generativ…

q-bio.BM2024★ 2 cited

Full-Atom Peptide Design based on Multi-modal Flow Matching

Jiahan Li, Chaoran Cheng, Zuofan Wu +5

Peptides, short chains of amino acid residues, play a vital role in numerous biological processes by interacting with other target molecules, offering substantial potential in drug…

cs.LG2024

Categorical Flow Matching on Statistical Manifolds

Chaoran Cheng, Jiahan Li, Jian Peng +1

We introduce Statistical Flow Matching (SFM), a novel and mathematically rigorous flow-matching framework on the manifold of parameterized probability measures inspired by the resu…

cs.LG2023

Equivariant Neural Operator Learning with Graphon Convolution

Chaoran Cheng, Jian Peng

We propose a general architecture that combines the coefficient learning scheme with a residual operator layer for learning mappings between continuous functions in the 3D Euclidea…