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q-bio.QM2025
HyperADRs: A Hierarchical Hypergraph Framework for Drug-Gene-ADR Prediction
Ze Cai, Haotian Tang, Shuai Gao +3
Adverse drug reactions (ADRs) are a major barrier to safe and effective pharmacotherapy and increasingly reflect higher order interactions between drugs, genetic background, and cl…
q-bio.QM2025
SynCell: Contextualized Drug Synergy Prediction
Keqin Peng, Guangxin Su, Qinshan Shi +4
Drug synergy is profoundly influenced by cellular context, as variations in protein interaction landscapes and pathway activities across cell types reshape how drugs act in combina…