3 papers
stat.ME2026
A Multi-Stage Drop-the-Loser Design with Superiority Boundaries
Peter Greenstreet, Manel Khan, Salmaan Kanji +4
Multi-arm multi-stage (MAMS) trials have gained popularity, due to their improved efficiency in evaluating multiple treatments. A traditional MAMS trial often decreases the expecte…
stat.ME2025
A multi-arm multi-stage design for trials with all pairwise testing
Peter Greenstreet, Thomas Jaki, Alun Bedding +1
Multi-arm multi-stage (MAMS) trials have gained popularity to enhance the efficiency of clinical trials, potentially reducing both duration and costs. This paper focuses on designi…
stat.ME2023
Design of platform trials with a change in the control treatment arm
Peter Greenstreet, Thomas Jaki, Alun Bedding +1
Platform trials are a more efficient way of testing multiple treatments compared to running separate trials. In this paper we consider platform trials where, if a treatment is foun…