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q-bio.GN2026
Generalizable single-cell perturbation response prediction using energy-guided flow matching
Jianan Wei, Jiajun Hong, Guikun Chen +3
Predicting phenotypic and transcriptional responses to perturbations at single-cell resolution provides a powerful tool for probing biological systems. However, existing methods ty…
eess.IV2026
Tractogram foundation model
Guikun Chen, Yuqian Chen, Yijie Li +5
Diffusion MRI (dMRI) tractography is the only noninvasive approach for mapping white-matter pathways in the living human brain. It represents each brain as a tractogram: a large, u…