30 citations · 67 across the 7 of their papers we have counts for
7 papers
Best Practices on QSP Model Reporting for Regulatory Use: perspectives from ISoP QSP SIG Working Group
Susana Zaph, Blerta Shtylla, Steve Chang +12
Quantitative systems pharmacology (QSP) models are increasingly applied to inform decision making across drug development and to support regulatory interactions within model inform…
Order-of-mutation effects on cancer progression: models for myeloproliferative neoplasm
Yue Wang, Blerta Shtylla, Tom Chou
We develop a modeling framework for cancer progression that distinguishes the order of two possible mutations. Recent observations and information on myeloproliferative neoplasms a…
A machine learning approach to using Quality-of-Life patient scores in guiding prostate radiation therapy dosing
Zhijian Yang, Daniel Olszewski, Chujun He +5
Thanks to advancements in diagnosis and treatment, prostate cancer patients have high long-term survival rates. Currently, an important goal is to preserve quality-of-life during a…
A Stochastic Multiscale Model that Explains the Segregation of Axonal Microtubules and Neurofilaments in Neurological Diseases
Chuan Xue, Blerta Shtylla, Anthony Brown
The organization of the axonal cytoskeleton is a key determinant of the normal function of an axon, which is a long thin projection away from a neuron. Under normal conditions two…
Distribution of lifetimes of kinetochore-microtubule attachments: interplay of energy landscape, molecular motors and microtubule (de-)polymerization
Ajeet K. Sharma, Blerta Shtylla, Debashish Chowdhury
Before a cell divides into two daughter cells, chromosomes are replicated resulting in two sister chromosomes embracing each other. Each sister chromosome is bound to a separate pr…
A theoretical model for attachment lifetimes of kinetochore-microtubules: Mechano-kinetic "catch-bond" mechanism for error-correction
Blerta Shtylla, Debashish Chowdhury
Before cell division, two identical copies of chromosomes are pulled apart by microtubule (MT) filaments that approach the chromosomes from the opposite poles a mitotic spindle. Co…