1 citations · 1 across the 4 of their papers we have counts for
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Lower Ricci Curvature for Hypergraphs
Shiyi Yang, Can Chen, Didong Li
Networks with higher-order interactions, prevalent in biological, social, and information systems, are naturally represented as hypergraphs, yet their structural complexity poses f…
Structure-Aligned Protein Language Model
Can Chen, David Heurtel-Depeiges, Robert M. Vernon +3
Protein language models (pLMs) pre-trained on vast protein sequence databases excel at various downstream tasks but often lack the structural knowledge essential for some biologica…
Offline Model-Based Optimization: Comprehensive Review
Minsu Kim, Jiayao Gu, Ye Yuan +4
Offline optimization is a fundamental challenge in science and engineering, where the goal is to optimize black-box functions using only offline datasets. This setting is particula…
AffinityFlow: Guided Flows for Antibody Affinity Maturation
Can Chen, Karla-Luise Herpoldt, Chenchao Zhao +4
Antibodies are widely used as therapeutics, but their development requires costly affinity maturation, involving iterative mutations to enhance binding affinity.This paper explores…