3 papers
q-bio.QM2025
Modeling cell differentiation in neuroblastoma: insights into development, malignancy, and treatment relapse
Simon F. Martina-Perez, Luke A. Heirene, Jennifer C. Kasemeier +2
Neuroblastoma is a paediatric extracranial solid cancer that arises from the developing sympathetic nervous system and is characterised by an abnormal distribution of cell types in…
q-bio.QM2025
Optimal control in combination therapy for heterogeneous cell populations with drug synergies
Simon F. Martina-Perez, Samuel W. S. Johnson, Rebecca M. Crossley +3
Cell heterogeneity plays an important role in patient responses to drug treatments. In many cancers, it is associated with poor treatment outcomes. Many modern drug combination the…
q-bio.CB2022
Dynamic fibronectin assembly and remodeling by leader neural crest cells prevents jamming in collective cell migration
W. Duncan Martinson, Rebecca McLennan, Jessica M. Teddy +6
Collective cell migration plays an essential role in vertebrate development, yet the extent to which dynamically changing microenvironments influence this phenomenon remains unclea…