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A frequentist local false discovery rate
Daniel Xiang, Jake A. Soloff, William Fithian
The local false discovery rate (lfdr) of Efron et al. (2001) enjoys major conceptual and decision-theoretic advantages over the false discovery rate (FDR) as an error criterion in…
Non-standard boundary behaviour in two-component mixture models
Heather Battey, Peter McCullagh, Daniel Xiang
Consider a binary mixture model of the form , where is standard Gaussian and is a completely specified heavy-tailed distribution with the same sup…
Interpretation of local false discovery rates under the zero assumption
Daniel Xiang, Nikolaos Ignatiadis, Peter McCullagh
In large-scale studies with parallel signal-plus-noise observations, the local false discovery rate is a summary statistic that is often presumed to be equal to the posterior proba…
Sparse-limit approximation for t-statistics
Micol Tresoldi, Daniel Xiang, Peter McCullagh
In a range of genomic applications, it is of interest to quantify the evidence that the signal at site~ is active given conditionally independent replicate observations summariz…