121 citations · 348 across the 5 of their papers we have counts for
5 papers
A general reaction network unifies the aggregation behaviour of the A42 peptide and its variants
Georg Meisl, Xiaoting Yang, Christopher M. Dobson +2
The amyloid peptide (A42), whose aggregation is associated with Alzheimer's disease, is an amphiphatic peptide with a high propensity to self-assemble. A42 has a net nega…
Nucleated polymerisation in the presence of pre-formed seed filaments
Samuel I. A. Cohen, Michele Vendruscolo, Christopher M. Dobson +1
We revisit the classical problem of nucleated polymerisation and derive a range of exact results describing polymerisation in systems intermediate between the well-known limiting c…
Generic Mechanism of Emergence of Amyloid Protofilaments from Disordered Oligomeric aggregates
Stefan Auer, Filip Meersman, Christopher M. Dobson +1
The presence of oligomeric aggregates, which is often observed during the process of amyloid formation, has recently attracted much attention since it has been associated with neur…
Self-Templated Nucleation in Peptide and Protein aggregation
Stefan Auer, Christopher M. Dobson, Michele Vendruscolo +1
Peptides and proteins exhibit a common tendency to assemble into highly ordered fibrillar aggregates, whose formation proceeds in a nucleation-dependent manner that is often preced…
Importance of Metastable States in the Free Energy Landscapes of Polypeptide Chains
Stefan Auer, Mark A. Miller, Sergei V. Krivov +3
We show that the interplay between excluded volume effects, hydrophobicity, and hydrogen bonding of a tube-like representation of a polypeptide chain gives rise to free energy land…