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Predicting diverse M-best protein contact maps
Siqi Sun, Jianzhu Ma, Sheng Wang +1
Protein contacts contain important information for protein structure and functional study, but contact prediction from sequence information remains very challenging. Recently evolu…
MRFalign: Protein Homology Detection through Alignment of Markov Random Fields
Jianzhu Ma, Sheng Wang, Zhiyong Wang +1
Sequence-based protein homology detection has been extensively studied and so far the most sensitive method is based upon comparison of protein sequence profiles, which are derived…
Protein Contact Prediction by Integrating Joint Evolutionary Coupling Analysis and Supervised Learning
Jianzhu Ma, Sheng Wang, Zhiyong Wang +1
Protein contacts contain important information for protein structure and functional study, but contact prediction from sequence remains very challenging. Both evolutionary coupling…
Hydropathy Conformational Letter and its Substitution Matrix HP-CLESUM: an Application to Protein Structural Alignment
Sheng Wang
Motivation: Protein sequence world is discrete as 20 amino acids (AA) while its structure world is continuous, though can be discretized into structural alphabets (SA). In order to…
CLeFAPS: Fast Flexible Alignment of Protein Structures Based on Conformational Letters
Sheng Wang
CLeFAPS, a fast and flexible pairwise structural alignment algorithm based on a rigid-body framework, namely CLePAPS, is proposed. Instead of allowing twists (or bends), the flexib…
CLePAPS: Fast Pair Alignment of Protein Structures Based on Conformational Letters
Sheng Wang, Wei-Mou Zheng
Fast, efficient and reliable algorithms for pairwise alignment of protein structures are in ever increasing demand for analyzing the rapidly growing data of protein structures. CLe…